Ontology highlight
ABSTRACT:
SUBMITTER: Hsu FC
PROVIDER: S-EPMC4810436 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Hsu Fan-Chi FC Shapiro Michael J MJ Dash Barsha B Chen Chien-Chang CC Constans Megan M MM Chung Ji Young JY Romero Arocha Sinibaldo R SR Belmonte Paul J PJ Chen Meibo W MW McWilliams Douglas C DC Shapiro Virginia Smith VS
Scientific reports 20160329
The transcription factor Runx1 has essential roles throughout hematopoiesis. Here, we demonstrate that Runx1 is critical for T cell maturation. Peripheral naïve CD4(+) T cells from CD4-cre Runx1 cKO mice are phenotypically and functionally immature as shown by decreased production of TNF-α upon TCR stimulation. The loss of peripheral CD4(+) T cells in CD4-cre Runx1 cKO mice is not due to defects in homeostasis or decreased expression of IL-7Rα, as transgenic expression of IL-7Rα does not rescue ...[more]