Ontology highlight
ABSTRACT:
SUBMITTER: Ou X
PROVIDER: S-EPMC6804577 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Ou Xijun X Huo Jianxin J Huang Yuhan Y Li Yan-Feng YF Xu Shengli S Lam Kong-Peng KP
Cellular & molecular immunology 20180302 6
Invariant natural killer T (iNKT) cells develop from CD4<sup>+</sup>CD8<sup>+</sup> double-positive (DP) thymocytes and express an invariant V<sub>α</sub>14-J<sub>α</sub>18 T-cell receptor (TCR) α-chain. Generation of these cells requires the prolonged survival of DP thymocytes to allow for V<sub>α</sub>14-J<sub>α</sub>18 gene rearrangements and strong TCR signaling to induce the expression of the iNKT lineage-specific transcription factor PLZF. Here, we report that the transcription factor Yin ...[more]