Characterization of Antibody Bipolar Bridging Mediated by the Human Cytomegalovirus Fc Receptor gp68.
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ABSTRACT:
SUBMITTER: Ndjamen B
PROVIDER: S-EPMC4810659 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Publications
Characterization of Antibody Bipolar Bridging Mediated by the Human Cytomegalovirus Fc Receptor gp68.
Ndjamen Blaise B Joshi Devashish S DS Fraser Scott E SE Bjorkman Pamela J PJ
Journal of virology 20160106 6
The human cytomegalovirus glycoprotein gp68 functions as an Fc receptor for host IgGs and can form antibody bipolar bridging (ABB) complexes in which gp68 binds the Fc region of an antigen-bound IgG. Here we show that gp68-mediated endocytosis transports ABB complexes into endosomes, after which the complex is routed to lysosomes, presumably for degradation. These results suggest gp68 contributes to evasion of IgG-mediated immune responses by mediating destruction of host IgG and viral antigens. ...[more]
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