Ontology highlight
ABSTRACT:
SUBMITTER: Bukhari SIA
PROVIDER: S-EPMC4811377 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Bukhari Syed I A SIA Truesdell Samuel S SS Lee Sooncheol S Kollu Swapna S Classon Anthony A Boukhali Myriam M Jain Esha E Mortensen Richard D RD Yanagiya Akiko A Sadreyev Ruslan I RI Haas Wilhelm W Vasudevan Shobha S
Molecular cell 20160301 5
MicroRNAs predominantly decrease gene expression; however, specific mRNAs are translationally upregulated in quiescent (G0) mammalian cells and immature Xenopus laevis oocytes by an FXR1a-associated microRNA-protein complex (microRNP) that lacks the microRNP repressor, GW182. Their mechanism in these conditions of decreased mTOR signaling, and therefore reduced canonical (cap-and-poly(A)-tail-mediated) translation, remains undiscovered. Our data reveal that mTOR inhibition in human THP1 cells en ...[more]