Unknown

Dataset Information

0

Neuronal Nicotinic Acetylcholine Receptor Modulators Reduce Sugar Intake.


ABSTRACT: Excess sugar consumption has been shown to contribute directly to weight gain, thus contributing to the growing worldwide obesity epidemic. Interestingly, increased sugar consumption has been shown to repeatedly elevate dopamine levels in the nucleus accumbens (NAc), in the mesolimbic reward pathway of the brain similar to many drugs of abuse. We report that varenicline, an FDA-approved nicotinic acetylcholine receptor (nAChR) partial agonist that modulates dopamine in the mesolimbic reward pathway of the brain, significantly reduces sucrose consumption, especially in a long-term consumption paradigm. Similar results were observed with other nAChR drugs, namely mecamylamine and cytisine. Furthermore, we show that long-term sucrose consumption increases ?4?2 * and decreases ?6?2* nAChRs in the nucleus accumbens, a key brain region associated with reward. Taken together, our results suggest that nAChR drugs such as varenicline may represent a novel treatment strategy for reducing sugar consumption.

SUBMITTER: Shariff M 

PROVIDER: S-EPMC4814119 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

altmetric image

Publications

Neuronal Nicotinic Acetylcholine Receptor Modulators Reduce Sugar Intake.

Shariff Masroor M   Quik Maryka M   Holgate Joan J   Morgan Michael M   Patkar Omkar L OL   Tam Vincent V   Belmer Arnauld A   Bartlett Selena E SE  

PloS one 20160330 3


Excess sugar consumption has been shown to contribute directly to weight gain, thus contributing to the growing worldwide obesity epidemic. Interestingly, increased sugar consumption has been shown to repeatedly elevate dopamine levels in the nucleus accumbens (NAc), in the mesolimbic reward pathway of the brain similar to many drugs of abuse. We report that varenicline, an FDA-approved nicotinic acetylcholine receptor (nAChR) partial agonist that modulates dopamine in the mesolimbic reward path  ...[more]

Similar Datasets

| S-EPMC6024932 | biostudies-literature
| S-EPMC3055681 | biostudies-literature
| S-EPMC153771 | biostudies-literature
| S-EPMC6301012 | biostudies-literature
| S-EPMC4238110 | biostudies-literature
| S-EPMC6658922 | biostudies-literature
| S-EPMC7723979 | biostudies-literature
| S-EPMC6901503 | biostudies-literature
| S-EPMC3162128 | biostudies-literature
| S-EPMC2760105 | biostudies-literature