Ontology highlight
ABSTRACT:
SUBMITTER: Shariff M
PROVIDER: S-EPMC4814119 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Shariff Masroor M Quik Maryka M Holgate Joan J Morgan Michael M Patkar Omkar L OL Tam Vincent V Belmer Arnauld A Bartlett Selena E SE
PloS one 20160330 3
Excess sugar consumption has been shown to contribute directly to weight gain, thus contributing to the growing worldwide obesity epidemic. Interestingly, increased sugar consumption has been shown to repeatedly elevate dopamine levels in the nucleus accumbens (NAc), in the mesolimbic reward pathway of the brain similar to many drugs of abuse. We report that varenicline, an FDA-approved nicotinic acetylcholine receptor (nAChR) partial agonist that modulates dopamine in the mesolimbic reward path ...[more]