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Brain imaging demonstrates a reduced neural impact of eating in obesity.

ABSTRACT: This study investigated functional brain response differences to food in women with BMI either <25 kg/m(2) (lean) or >35 kg/m(2) (severe obesity).Thirty women, 18-65 years old, from academic medical centers participated. Baseline brain perfusion was measured with arterial spin labeling. Brain activity was measured via blood-oxygen-level-dependent functional magnetic resonance imaging in response to food cues, and appeal to cues was rated. Subjective hunger/fullness was reported pre- and post-imaging. After a standard meal, measures were repeated.When fasting, brain perfusion did not differ significantly between groups; and both groups showed significantly increased activity in the neo- and limbic cortices and midbrain compared with baseline (P?

SUBMITTER: Puzziferri N

PROVIDER: S-EPMC4814322 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature

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Brain imaging demonstrates a reduced neural impact of eating in obesity.

Puzziferri Nancy N Zigman Jeffrey M JM Thomas Binu P BP Mihalakos Perry P Gallagher Ryan R Lutter Michael M Carmody Thomas T Lu Hanzhang H Tamminga Carol A CA

Obesity (Silver Spring, Md.) 20160219 4

<h4>Objective</h4>This study investigated functional brain response differences to food in women with BMI either <25 kg/m(2) (lean) or >35 kg/m(2) (severe obesity).<h4>Design and methods</h4>Thirty women, 18-65 years old, from academic medical centers participated. Baseline brain perfusion was measured with arterial spin labeling. Brain activity was measured via blood-oxygen-level-dependent functional magnetic resonance imaging in response to food cues, and appeal to cues was rated. Subjective h ...[more]

PMID: 26891710

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