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Brain imaging demonstrates a reduced neural impact of eating in obesity.

ABSTRACT: This study investigated functional brain response differences to food in women with BMI either <25 kg/m(2) (lean) or >35 kg/m(2) (severe obesity).Thirty women, 18-65 years old, from academic medical centers participated. Baseline brain perfusion was measured with arterial spin labeling. Brain activity was measured via blood-oxygen-level-dependent functional magnetic resonance imaging in response to food cues, and appeal to cues was rated. Subjective hunger/fullness was reported pre- and post-imaging. After a standard meal, measures were repeated.When fasting, brain perfusion did not differ significantly between groups; and both groups showed significantly increased activity in the neo- and limbic cortices and midbrain compared with baseline (P?

SUBMITTER: Puzziferri N

PROVIDER: S-EPMC4814322 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature

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Brain imaging demonstrates a reduced neural impact of eating in obesity.

Puzziferri Nancy N Zigman Jeffrey M JM Thomas Binu P BP Mihalakos Perry P Gallagher Ryan R Lutter Michael M Carmody Thomas T Lu Hanzhang H Tamminga Carol A CA

Obesity (Silver Spring, Md.) 20160219 4

<h4>Objective</h4>This study investigated functional brain response differences to food in women with BMI either <25 kg/m(2) (lean) or >35 kg/m(2) (severe obesity).<h4>Design and methods</h4>Thirty women, 18-65 years old, from academic medical centers participated. Baseline brain perfusion was measured with arterial spin labeling. Brain activity was measured via blood-oxygen-level-dependent functional magnetic resonance imaging in response to food cues, and appeal to cues was rated. Subjective h ...[more]

PMID: 26891710

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Project description:BackgroundTime restricted eating (TRE), limiting eating to a specific daily window, is a novel dietary intervention, but the mechanisms by which TRE results in weight loss remain unclear. The goal of the current study was to examine changes in eating patterns, sleep, and late-night eating, and associations with health outcomes in a secondary analysis of a 12-week self-selected TRE intervention.MethodsTwenty participants 18-65 years with BMI ≥25 kg/m2 completed the 12-week trial. Participants randomized to TRE (n = 11) were instructed to eat during a self-selected 8-h window, while the non-TRE group (n = 9) followed their typical eating habits. All participants logged oral intake using the myCircadian Clock mobile application throughout the entire intervention. Anthropometrics, HbA1c, an oral glucose tolerance test, and 2 weeks of actigraphy monitoring were completed at pre-intervention and end-intervention. Independent samples t-tests compared differences between groups. Data are presented as mean ± standard deviation.ResultsAt preintervention, late night eating was significantly associated with higher fasting glucose (r = 0.59, p = 0.006) and higher HbA1c (r = 0.46, p = 0.016). The TRE group significantly delayed the timing of the first eating occasion by 2.72 ± 1.48 h relative to wake time (p < 0.001) and advanced the timing of the last eating occasion by 1.25 ± 0.8 h relative to bedtime (p < 0.001). The non-TRE group, on average, maintained their eating pattern. Sleep measures did not change from pre- to end-intervention, however greater restriction of the eating window was associated with longer sleep duration at end-intervention (β = -0.46 [95% CI -9.2, -0.4], p = 0.03). The TRE group significantly reduced the prevalence of late night eating (eating within 2 h of bedtime) by 14 ± 6% (p = 0.028) with 63% of participants completely eliminating late night eating at end-intervention.ConclusionA self-selected TRE intervention significantly shifted meal timing, reduced late-night eating while prolonging sleep duration.Trial registryClinicalTrials.gov, identifier: 03129581.

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Brain imaging demonstrates a reduced neural impact of eating in obesity.

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Brain imaging demonstrates a reduced neural impact of eating in obesity.

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