Ontology highlight
ABSTRACT:
SUBMITTER: Wall DS
PROVIDER: S-EPMC2615087 | biostudies-other | 2009 Jan
REPOSITORIES: biostudies-other
Wall Dana S DS Mears Alan J AJ McNeill Brian B Mazerolle Chantal C Thurig Sherry S Wang Yaping Y Kageyama Ryoichiro R Wallace Valerie A VA
The Journal of cell biology 20090105 1
Sonic hedgehog (Shh) is an indispensable, extrinsic cue that regulates progenitor and stem cell behavior in the developing and adult mammalian central nervous system. Here, we investigate the link between the Shh signaling pathway and Hes1, a classical Notch target. We show that Shh-driven stabilization of Hes1 is independent of Notch signaling and requires the Shh effector Gli2. We identify Gli2 as a primary mediator of this response by showing that Gli2 is required for Hh (Hedgehog)-dependent ...[more]