Ontology highlight
ABSTRACT:
SUBMITTER: Suzuki A
PROVIDER: S-EPMC4814359 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Suzuki Aussie A Badger Benjamin L BL Haase Julian J Ohashi Tomoo T Erickson Harold P HP Salmon Edward D ED Bloom Kerry K
Nature cell biology 20160314 4
The Ndc80 complex (Ndc80, Nuf2, Spc24 and Spc25) is a highly conserved kinetochore protein essential for end-on anchorage to spindle microtubule plus ends and for force generation coupled to plus-end polymerization and depolymerization. Spc24/Spc25 at one end of the Ndc80 complex binds the kinetochore. The N-terminal tail and CH domains of Ndc80 bind microtubules, and an internal domain binds microtubule-associated proteins (MAPs) such as the Dam1 complex. To determine how the microtubule- and M ...[more]