Ontology highlight
ABSTRACT:
SUBMITTER: Lera RF
PROVIDER: S-EPMC6776907 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Lera Robert F RF Norman Roshan X RX Dumont Marie M Dennee Alexandra A Martin-Koob Joanne J Fachinetti Daniele D Burkard Mark E ME
EMBO reports 20190830 10
During mitosis, sister chromatids attach to microtubules which generate ~ 700 pN pulling force focused on the centromere. We report that chromatin-localized signals generated by Polo-like kinase 1 (Plk1) maintain the integrity of the kinetochore and centromere against this force. Without sufficient Plk1 activity, chromosomes become misaligned after normal condensation and congression. These chromosomes are silent to the mitotic checkpoint, and many lag and mis-segregate in anaphase. Their centro ...[more]