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Lewis acid-promoted [2 + 2] cycloadditions of alkenes with aryl ketenes.

ABSTRACT: A method for the [2 + 2] cycloaddition of aryl ketenes and alkenes is presented. The process involves the in situ generation of a ketene in the presence of a Lewis acid. The utility of products is demonstrated towards the synthesis of a common scaffold found in several natural product families.

SUBMITTER: Rigsbee EM

PROVIDER: S-EPMC4814371 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature

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Lewis acid-promoted [2 + 2] cycloadditions of alkenes with aryl ketenes.

Rigsbee E M EM Zhou C C Rasik C M CM Spitz A Z AZ Nichols A J AJ Brown M K MK

Organic & biomolecular chemistry 20150930 24

A method for the [2 + 2] cycloaddition of aryl ketenes and alkenes is presented. The process involves the in situ generation of a ketene in the presence of a Lewis acid. The utility of products is demonstrated towards the synthesis of a common scaffold found in several natural product families. ...[more]

PMID: 26419921

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