Ontology highlight
ABSTRACT:
SUBMITTER: Lavoie CM
PROVIDER: S-EPMC4814586 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Nature communications 20160323
Palladium-catalysed C(sp(2))-N cross-coupling (that is, Buchwald-Hartwig amination) is employed widely in synthetic chemistry, including in the pharmaceutical industry, for the synthesis of (hetero)aniline derivatives. However, the cost and relative scarcity of palladium provides motivation for the development of alternative, more Earth-abundant catalysts for such transformations. Here we disclose an operationally simple and air-stable ligand/nickel(II) pre-catalyst that accommodates the broades ...[more]