Ontology highlight
ABSTRACT:
SUBMITTER: Li C
PROVIDER: S-EPMC5792186 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Li Chao C Kawamata Yu Y Nakamura Hugh H Vantourout Julien C JC Liu Zhiqing Z Hou Qinglong Q Bao Denghui D Starr Jeremy T JT Chen Jinshan J Yan Ming M Baran Phil S PS
Angewandte Chemie (International ed. in English) 20170914 42
Along with amide bond formation, Suzuki cross-coupling, and reductive amination, the Buchwald-Hartwig-Ullmann-type amination of aryl halides stands as one of the most employed reactions in modern medicinal chemistry. The work herein demonstrates the potential of utilizing electrochemistry to provide a complementary avenue to access such critical bonds using an inexpensive nickel catalyst under mild reaction conditions. Of note is the scalability, functional-group tolerance, rapid rate, and the a ...[more]