Ontology highlight
ABSTRACT:
SUBMITTER: Vicente EF
PROVIDER: S-EPMC4814773 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
The journal of physical chemistry. B 20150702 28
The human enzyme dihydroorotate dehydrogenase (HsDHODH) has been studied for being a target for development of new antineoplasic and antiproliferative drugs. The synthetic peptide N-t(DH) represents the N-terminal microdomain of this enzyme, responsible for anchoring it to the inner mitochondrial membrane. Also, it is known to harbor quinones that are essential for enzyme catalysis. Here we report structural features of the peptide/membrane interactions obtained by using CD and DEER spectroscopi ...[more]