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Is serum sex hormone-binding globulin a dominant risk factor for metabolic syndrome?


ABSTRACT: This multi-center, cross-sectional study investigated the association between serum testosterone (T) levels, serum sex hormone-binding globulin (SHBG) levels, and the risk of metabolic syndrome (MS) in 3332 adult Chinese men. The prevalence of MS was 34.7%, and men with MS had lower serum levels of total T (TT) and SHBG than those without MS (P < 0.001). There was no significant difference in serum free T (FT) levels between subjects with and without MS (P = 0.627). In logistic regression analysis, the association between MS and serum SHBG levels persisted after adjusting for age, body mass index (BMI), smoking and drinking status, and serum TT (odds ratio [OR] 0.962, 95% confidence interval [95% CI] 0.954-0.969, P< 0.01). However, the association between serum TT level and the risk of MS was weak after adjusting for age, BMI, SHBG level, and smoking and drinking status (OR 0.981, 95% CI 0.960-1.007). Our study reveals that both serum TT and SHBG levels, but not serum FT, are inversely associated with the prevalence of MS and that serum SHBG is an independent and dominant risk factor for MS.

SUBMITTER: Yang YH 

PROVIDER: S-EPMC4814971 | biostudies-literature | 2015 Nov-Dec

REPOSITORIES: biostudies-literature

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Is serum sex hormone-binding globulin a dominant risk factor for metabolic syndrome?

Yang Yi-Hong YH   Zhao Ming-Jia MJ   Zhou Shan-Jie SJ   Lu Wen-Hong WH   Liang Xiao-Wei XW   Xiong Cheng-Liang CL   Wan Chang-Chun CC   Shang Xue-Jun XJ   Gu Yi-Qun YQ  

Asian journal of andrology 20151101 6


This multi-center, cross-sectional study investigated the association between serum testosterone (T) levels, serum sex hormone-binding globulin (SHBG) levels, and the risk of metabolic syndrome (MS) in 3332 adult Chinese men. The prevalence of MS was 34.7%, and men with MS had lower serum levels of total T (TT) and SHBG than those without MS (P < 0.001). There was no significant difference in serum free T (FT) levels between subjects with and without MS (P = 0.627). In logistic regression analys  ...[more]

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