Ontology highlight
ABSTRACT:
SUBMITTER: Huculeci R
PROVIDER: S-EPMC4815226 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Huculeci Radu R Garcia-Pino Abel A Buts Lieven L Lenaerts Tom T van Nuland Nico N
Protein science : a publication of the Protein Society 20151007 12
Src homology 2 domains are interaction modules dedicated to the recognition of phosphotyrosine sites incorporated in numerous proteins found in intracellular signaling pathways. Here we provide for the first time structural insight into the dimerization of Fyn SH2 both in solution and in crystalline conditions, providing novel crystal structures of both the dimer and peptide-bound structures of Fyn SH2. Using nuclear magnetic resonance chemical shift analysis, we show how the peptide is able to ...[more]