In vivo epigenetic reprogramming of primary human colon cancer cells enhances metastases.
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ABSTRACT:
SUBMITTER: Singovski G
PROVIDER: S-EPMC4816146 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Publications
In vivo epigenetic reprogramming of primary human colon cancer cells enhances metastases.
Singovski Grigori G Bernal Carolina C Kuciak Monika M Siegl-Cachedenier Irene I Conod Arwen A Ruiz i Altaba Ariel A
Journal of molecular cell biology 20150601 2
How metastases develop is not well understood and no genetic mutations have been reported as specific metastatic drivers. Here we have addressed the idea that epigenetic reprogramming by GLI-regulated pluripotent stemness factors promotes metastases. Using primary human colon cancer cells engrafted in mice, we find that transient expression of OCT4, SOX2, KLF4 +/- cMYC establishes an enhanced pro-metastatic state in the primary tumor that is stable through sequential engraftments and is transmit ...[more]
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