Ontology highlight
ABSTRACT:
SUBMITTER: Hayes TK
PROVIDER: S-EPMC4816652 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Cancer cell 20151224 1
Induction of compensatory mechanisms and ERK reactivation has limited the effectiveness of Raf and MEK inhibitors in RAS-mutant cancers. We determined that direct pharmacologic inhibition of ERK suppressed the growth of a subset of KRAS-mutant pancreatic cancer cell lines and that concurrent phosphatidylinositol 3-kinase (PI3K) inhibition caused synergistic cell death. Additional combinations that enhanced ERK inhibitor action were also identified. Unexpectedly, long-term treatment of sensitive ...[more]