Ontology highlight
ABSTRACT:
SUBMITTER: Wang J
PROVIDER: S-EPMC4873974 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Wang Jieqiong J Hu Kewen K Guo Jiawei J Cheng Feixiong F Lv Jing J Jiang Wenhao W Lu Weiqiang W Liu Jinsong J Pang Xiufeng X Liu Mingyao M
Nature communications 20160519
No effective targeted therapies exist for cancers with somatic KRAS mutations. Here we develop a synthetic lethal chemical screen in isogenic KRAS-mutant and wild-type cells to identify clinical drug pairs. Our results show that dual inhibition of polo-like kinase 1 and RhoA/Rho kinase (ROCK) leads to the synergistic effects in KRAS-mutant cancers. Microarray analysis reveals that this combinatory inhibition significantly increases transcription and activity of cyclin-dependent kinase inhibitor ...[more]