Ontology highlight
ABSTRACT:
SUBMITTER: Pelletier G
PROVIDER: S-EPMC4817112 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20160301 9
We report a synthetic glycosylation reaction between sucrosyl acceptors and glycosyl fluoride donors to yield the derived trisaccharides. This reaction proceeds at room temperature in an aqueous solvent mixture. Calcium salts and a tertiary amine base promote the reaction with high site-selectivity for either the 3'-position or 1'-position of the fructofuranoside unit. Because nonenzymatic aqueous oligosaccharide syntheses are underdeveloped, mechanistic studies were carried out in order to iden ...[more]