Ontology highlight
ABSTRACT:
SUBMITTER: Li M
PROVIDER: S-EPMC4817766 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Li Mingkun M Rothwell Rebecca R Vermaat Martijn M Wachsmuth Manja M Schröder Roland R Laros Jeroen F J JF van Oven Mannis M de Bakker Paul I W PI Bovenberg Jasper A JA van Duijn Cornelia M CM van Ommen Gert-Jan B GJ Slagboom P Eline PE Swertz Morris A MA Wijmenga Cisca C Kayser Manfred M Boomsma Dorret I DI Zöllner Sebastian S de Knijff Peter P Stoneking Mark M
Genome research 20160225 4
Although previous studies have documented a bottleneck in the transmission of mtDNA genomes from mothers to offspring, several aspects remain unclear, including the size and nature of the bottleneck. Here, we analyze the dynamics of mtDNA heteroplasmy transmission in the Genomes of the Netherlands (GoNL) data, which consists of complete mtDNA genome sequences from 228 trios, eight dizygotic (DZ) twin quartets, and 10 monozygotic (MZ) twin quartets. Using a minor allele frequency (MAF) threshold ...[more]