Ontology highlight
ABSTRACT:
SUBMITTER: Seifert FU
PROVIDER: S-EPMC4818761 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Seifert Florian Ulrich FU Lammens Katja K Stoehr Gabriele G Kessler Brigitte B Hopfner Karl-Peter KP
The EMBO journal 20160219 7
The Mre11-Rad50-Nbs1 (MRN) complex is a central factor in the repair of DNA double-strand breaks (DSBs). The ATP-dependent mechanisms of how MRN detects and endonucleolytically processes DNA ends for the repair by microhomology-mediated end-joining or further resection in homologous recombination are still unclear. Here, we report the crystal structures of the ATPγS-bound dimer of the Rad50(NBD)(nucleotide-binding domain) from the thermophilic eukaryote Chaetomium thermophilum(Ct) in complex wit ...[more]