Ontology highlight
ABSTRACT:
SUBMITTER: Altman BJ
PROVIDER: S-EPMC4818967 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Cell metabolism 20150917 6
The MYC oncogene encodes MYC, a transcription factor that binds the genome through sites termed E-boxes (5'-CACGTG-3'), which are identical to the binding sites of the heterodimeric CLOCK-BMAL1 master circadian transcription factor. Hence, we hypothesized that ectopic MYC expression perturbs the clock by deregulating E-box-driven components of the circadian network in cancer cells. We report here that deregulated expression of MYC or N-MYC disrupts the molecular clock in vitro by directly induci ...[more]