Ontology highlight
ABSTRACT:
SUBMITTER: Blazevits O
PROVIDER: S-EPMC7177918 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
International journal of molecular sciences 20200326 7
The circadian transcriptional network is based on a competition between transcriptional activator and repressor complexes regulating the rhythmic expression of clock-controlled genes. We show here that the MYC-associated factor X, MAX, plays a repressive role in this network and operates through a MYC-independent binding to E-box-containing regulatory regions within the promoters of circadian BMAL1 targets. We further show that this "clock" function of MAX is required for maintaining a proper ci ...[more]