Ontology highlight
ABSTRACT:
SUBMITTER: Berg RD
PROVIDER: S-EPMC4819607 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Berg Russell D RD Levitte Steven S O'Sullivan Mary P MP O'Leary Seónadh M SM Cambier C J CJ Cameron James J Takaki Kevin K KK Moens Cecilia B CB Tobin David M DM Keane Joseph J Ramakrishnan Lalita L
Cell 20160301 1
A zebrafish genetic screen for determinants of susceptibility to Mycobacterium marinum identified a hypersusceptible mutant deficient in lysosomal cysteine cathepsins that manifests hallmarks of human lysosomal storage diseases. Under homeostatic conditions, mutant macrophages accumulate undigested lysosomal material, which disrupts endocytic recycling and impairs their migration to, and thus engulfment of, dying cells. This causes a buildup of unengulfed cell debris. During mycobacterial infect ...[more]