Ontology highlight
ABSTRACT:
SUBMITTER: Roca FJ
PROVIDER: S-EPMC6736209 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Roca Francisco J FJ Whitworth Laura J LJ Redmond Sarah S Jones Ana A AA Ramakrishnan Lalita L
Cell 20190829 6
Necrosis of infected macrophages constitutes a critical pathogenetic event in tuberculosis by releasing mycobacteria into the growth-permissive extracellular environment. In zebrafish infected with Mycobacterium marinum or Mycobacterium tuberculosis, excess tumor necrosis factor triggers programmed necrosis of infected macrophages through the production of mitochondrial reactive oxygen species (ROS) and the participation of cyclophilin D, a component of the mitochondrial permeability transition ...[more]