High-throughput deep screening and identification of four peripheral leucocyte microRNAs as novel potential combination biomarkers for preeclampsia.
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ABSTRACT:
SUBMITTER: Wang Y
PROVIDER: S-EPMC4819758 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
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High-throughput deep screening and identification of four peripheral leucocyte microRNAs as novel potential combination biomarkers for preeclampsia.
Wang Yonghong Y Yang Xukui X Yang Yuanyuan Y Wang Wenjun W Zhao Meiling M Liu Huiqiang H Li Dongyan D Hao Min M
Journal of perinatology : official journal of the California Perinatal Association 20151217 4
<h4>Objective</h4>To identify the specific microRNA (miRNA) biomarkers of preeclampsia (PE), the miRNA profiles analysis were performed.<h4>Study design</h4>The blood samples were obtained from five PE patients and five normal healthy pregnant women. The small RNA profiles were analyzed to identify miRNA expression levels and find out miRNAs that may associate with PE. The quantitative reverse transcriptase-PCR (qRT-PCR) assay was used to validate differentially expressed peripheral leucocyte mi ...[more]
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