Ontology highlight
ABSTRACT:
SUBMITTER: Yamamoto A
PROVIDER: S-EPMC4819960 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Yamamoto Akihiro A Liu Ming-Yih MY Kurogi Katsuhisa K Sakakibara Yoichi Y Saeki Yuichi Y Suiko Masahito M Liu Ming-Cheh MC
Journal of biochemistry 20150611 6
Sulphation is known to be critically involved in the metabolism of acetaminophen in vivo. This study aimed to systematically identify the major human cytosolic sulfotransferase (SULT) enzyme(s) responsible for the sulphation of acetaminophen. A systematic analysis showed that three of the twelve human SULTs, SULT1A1, SULT1A3 and SULT1C4, displayed the strongest sulphating activity towards acetaminophen. The pH dependence of the sulphation of acetaminophen by each of these three SULTs was examine ...[more]