Ontology highlight
ABSTRACT:
SUBMITTER: Fang T
PROVIDER: S-EPMC4820396 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Fang Tao T Duarte Joao N JN Ling Jingjing J Li Zeyang Z Guzman Jonathan S JS Ploegh Hidde L HL
Angewandte Chemie (International ed. in English) 20160114 7
Antibody-drug conjugates (ADCs) of defined structure hold great promise for cancer therapies, but further advances are constrained by the complex structures of full-sized antibodies. Camelid-derived single-domain antibody fragments (VHHs or nanobodies) offer a possible solution to this challenge by providing expedited target screening and validation through switching between imaging and therapeutic activities. We used a nanobody (VHH7) specific for murine MHC-II and rendered "sortase-ready" for ...[more]