Ontology highlight
ABSTRACT:
SUBMITTER: Rhee M
PROVIDER: S-EPMC4820710 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Rhee Marie M Lee Seung-Hwan SH Kim Ji-Won JW Ham Dong-Sik DS Park Heon-Seok HS Yang Hae Kyung HK Shin Ju-Young JY Cho Jae-Hyoung JH Kim Young-Bum YB Youn Byung-Soo BS Sul Hei Sook HS Yoon Kun-Ho KH
Scientific reports 20160405
The preadipocyte factor 1 (Pref-1) is involved in the proliferation and differentiation of various precursor cells. However, the intracellular signaling pathways that control these processes and the role of Pref-1 in the pancreas remain poorly understood. Here, we showed that Pref-1 induces insulin synthesis and secretion via two independent pathways. The overexpression of Pref-1 activated MAPK signaling, which induced nucleocytoplasmic translocation of FOXO1 and PDX1 and led to the differentiat ...[more]