Ontology highlight
ABSTRACT:
SUBMITTER: Oh JE
PROVIDER: S-EPMC6441031 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Oh Ju Eun JE Choi Ok Kyung OK Park Ho Seon HS Jung Hye Seung HS Ryu Su Jeong SJ Lee Yong Deok YD Lee Seung-Ah SA Chung Sung Soo SS Choi Eun Young EY Lee Dong-Sup DS Gho Yong Song YS Lee Hakmo H Park Kyong Soo KS
Scientific reports 20190329 1
Transplantation of stem cell-derived insulin producing cells (IPCs) has been proposed as an alternative to islet transplantation for the treatment of diabetes mellitus. However, current IPC differentiation protocols are focused on generating functional cells from the pluripotent stem cells and tend to rely on multistep, long-term exposure to various exogenous factors. In this study, we addressed the observation that under stress, pancreatic β-cells release essential components that direct the di ...[more]