Ontology highlight
ABSTRACT:
SUBMITTER: Lin S
PROVIDER: S-EPMC4820739 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Lin Shuxian S Svoboda Kathy K H KK Feng Jian Q JQ Jiang Xinquan X
Bone research 20160405
Bone morphogenetic proteins (BMPs) have multiple roles in skeletal development, homeostasis and regeneration. BMPs signal via type I and type II serine/threonine kinase receptors (BMPRI and BMPRII). In recent decades, genetic studies in humans and mice have demonstrated that perturbations in BMP signaling via BMPRI resulted in various diseases in bone, cartilage, and muscles. In this review, we focus on all three types of BMPRI, which consist of activin-like kinase 2 (ALK2, also called type IA a ...[more]