Ontology highlight
ABSTRACT:
SUBMITTER: Yin H
PROVIDER: S-EPMC7031521 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Yin Hongen H Kalra Lovika L Lai Zhennan Z Guimaro Maria C MC Aber Lauren L Warner Blake M BM Michael Drew D Zhang Nan N Cabrera-Perez Javier J Karim Arif A Swaim William D WD Afione Sandra S Voigt Alexandria A Nguyen Cuong Q CQ Yu Paul B PB Bloch Donald B DB Chiorini John A JA
Scientific reports 20200219 1
Primary Sjögren's syndrome (pSS) is a chronic autoimmune disease, with only palliative treatments available. Recent work has suggested that increased bone morphogenetic protein 6 (BMP6) expression could alter cell signaling in the salivary gland (SG) and result in the associated salivary hypofunction. We examined the prevalence of elevated BMP6 expression in a large cohort of pSS patients and tested the therapeutic efficacy of BMP signaling inhibitors in two pSS animal models. Increased BMP6 exp ...[more]