Acute stress is detrimental to heart regeneration in zebrafish.
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ABSTRACT:
SUBMITTER: Sallin P
PROVIDER: S-EPMC4821245 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Publications
Acute stress is detrimental to heart regeneration in zebrafish.
Sallin Pauline P Jaźwińska Anna A
Open biology 20160301 3
Psychological stress is one of the factors associated with human cardiovascular disease. Here, we demonstrate that acute perceived stress impairs the natural capacity of heart regeneration in zebrafish. Beside physical and chemical disturbances, intermittent crowding triggered an increase in cortisol secretion and blocked the replacement of fibrotic tissue with new myocardium. Pharmacological simulation of stress by pulse treatment with dexamethasone/adrenaline reproduced the regeneration failur ...[more]
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