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Mitochondria-specific conjugated polymer nanoparticles.

ABSTRACT: Biodegradable conjugated polymer nanoparticles (CPNs) were prepared for high mitochondrial targeting in live cancer cells. The degradable CPNs are nontoxic and specifically localized to the mitochondria of live tumor cells through macropinocytosis followed by intracellular degradation and trafficking.

SUBMITTER: Twomey M

PROVIDER: S-EPMC4821631 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature

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Mitochondria-specific conjugated polymer nanoparticles.

Twomey Megan M Mendez Eladio E Manian Rajesh Kumar RK Lee Sunwoo S Moon Joong Ho JH

Chemical communications (Cambridge, England) 20160314 27

Biodegradable conjugated polymer nanoparticles (CPNs) were prepared for high mitochondrial targeting in live cancer cells. The degradable CPNs are nontoxic and specifically localized to the mitochondria of live tumor cells through macropinocytosis followed by intracellular degradation and trafficking. ...[more]

PMID: 26974193

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