Ontology highlight
ABSTRACT:
SUBMITTER: Kashyap MK
PROVIDER: S-EPMC4823073 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Kashyap Manoj K MK Kumar Deepak D Jones Harrison H Amaya-Chanaga Carlos I CI Choi Michael Y MY Melo-Cardenas Johanna J Ale-Ali Amine A Kuhne Michelle R MR Sabbatini Peter P Cohen Lewis J LJ Shelat Suresh G SG Rassenti Laura Z LZ Kipps Thomas J TJ Cardarelli Pina M PM Castro Januario E JE
Oncotarget 20160101 3
The CXCR4 receptor (Chemokine C-X-C motif receptor 4) is highly expressed in different hematological malignancies including chronic lymphocytic leukemia (CLL). The CXCR4 ligand (CXCL12) stimulates CXCR4 promoting cell survival and proliferation, and may contribute to the tropism of leukemia cells towards lymphoid tissues. Therefore, strategies targeting CXCR4 may constitute an effective therapeutic approach for CLL. To address that question, we studied the effect of Ulocuplumab (BMS-936564), a f ...[more]