Ontology highlight
ABSTRACT:
SUBMITTER: McQuary PR
PROVIDER: S-EPMC4823261 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Cell reports 20160225 9
Deficiency of S6 kinase (S6K) extends the lifespan of multiple species, but the underlying mechanisms are unclear. To discover potential effectors of S6K-mediated longevity, we performed a proteomics analysis of long-lived rsks-1/S6K C. elegans mutants compared to wild-type animals. We identified the arginine kinase ARGK-1 as the most significantly enriched protein in rsks-1/S6K mutants. ARGK-1 is an ortholog of mammalian creatine kinase, which maintains cellular ATP levels. We found that argk-1 ...[more]