Ontology highlight
ABSTRACT:
SUBMITTER: Dehghan E
PROVIDER: S-EPMC6817882 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Dehghan Esmaeil E Goodarzi Mohammad M Saremi Bahar B Lin Rueyling R Mirzaei Hamid H
Nature communications 20191028 1
Therapeutic activation of mitochondrial function has been suggested as an effective strategy to combat aging. Hydralazine is an FDA-approved drug used in the treatment of hypertension, heart failure and cancer. Hydralazine has been recently shown to promote lifespan in C. elegans, rotifer and yeast through a mechanism which has remained elusive. Here we report cAMP-dependent protein kinase (PKA) as the direct target of hydralazine. Using in vitro and in vivo models, we demonstrate a mechanism in ...[more]