Ontology highlight
ABSTRACT:
SUBMITTER: Wezel A
PROVIDER: S-EPMC4823661 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Wezel Anouk A de Vries Margreet R MR Maassen Johanna M JM Kip Peter P Peters Erna A EA Karper Jacco C JC Kuiper Johan J Bot Ilze I Quax Paul H A PHA
Scientific reports 20160407
Venous grafts are often used to bypass occlusive atherosclerotic lesions; however, poor patency leads to vein graft disease. Deficiency of TLR4, an inflammatory regulator, reduces vein graft disease. Here, we investigate the effects of the accessory molecule and TLR4 analogue RadioProtective 105 (RP105) on vein graft disease. RP105 deficiency resulted in a 90% increase in vein graft lesion area compared to controls. In a hypercholesterolemic setting (LDLr(-/-)/RP105(-/-) versus LDLr(-/-) mice), ...[more]