Ontology highlight
ABSTRACT:
SUBMITTER: Kobayashi W
PROVIDER: S-EPMC4823753 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Kobayashi Wataru W Takaku Motoki M Machida Shinichi S Tachiwana Hiroaki H Maehara Kazumitsu K Ohkawa Yasuyuki Y Kurumizaka Hitoshi H
Scientific reports 20160407
In eukaryotes, genomic DNA is compacted as chromatin, in which histones and DNA form the nucleosome as the basic unit. DMC1 and RAD51 are essential eukaryotic recombinases that mediate homologous chromosome pairing during homologous recombination. However, the means by which these two recombinases distinctly function in chromatin have remained elusive. Here we found that, in chromatin, the human DMC1-single-stranded DNA complex bypasses binding to the nucleosome, and preferentially promotes homo ...[more]