Ontology highlight
ABSTRACT:
SUBMITTER: Hanggi D
PROVIDER: S-EPMC4824023 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Hänggi Daniel D Etminan Nima N Steiger Hans Jakob HJ Johnson Mark M Peet M Melissa MM Tice Tom T Burton Kevin K Hudson Bruce B Turner Michele M Stella Angela A Heshmati Parissa P Davis Cara C Faleck Herbert J HJ Macdonald R Loch RL
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20160401 2
Nimodipine is the only drug approved for use by the Food and Drug Administration for improving outcome after aneurysmal subarachnoid hemorrhage (SAH). It has less than optimal efficacy, causes dose-limiting hypotension in a substantial proportion of patients, and is administered enterally 6 times daily. We describe development of site-specific, sustained-release nimodipine microparticles that can be delivered once directly into the subarachnoid space or cerebral ventricles for potential improvem ...[more]