Hyaluronan Inhibits Tlr-4-Dependent RANKL Expression in Human Rheumatoid Arthritis Synovial Fibroblasts.
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ABSTRACT:
SUBMITTER: Watanabe T
PROVIDER: S-EPMC4824426 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
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Hyaluronan Inhibits Tlr-4-Dependent RANKL Expression in Human Rheumatoid Arthritis Synovial Fibroblasts.
Watanabe Tatsuo T Takahashi Nobunori N Hirabara Shinya S Ishiguro Naoki N Kojima Toshihisa T
PloS one 20160407 4
The Toll-like receptor (TLR) signaling pathway is activated in synovial fibroblast cells in patients with rheumatoid arthritis (RA). The receptor activator of nuclear factor-κB (RANK) and its ligand, RANKL, are key molecules involved in the differentiation of osteoclasts and joint destruction in RA. Hyaluronan (HA) is a major extracellular component and an important immune regulator. In this study, we show that lipopolysaccharide (LPS) stimulation significantly increases RANKL expression via a T ...[more]
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