Ontology highlight
ABSTRACT:
SUBMITTER: Zhu M
PROVIDER: S-EPMC4824659 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Zhu Mingqin M Wang Xiuzhe X Hjorth Erik E Colas Romain A RA Schroeder Lisa L Granholm Ann-Charlotte AC Serhan Charles N CN Schultzberg Marianne M
Molecular neurobiology 20151209 4
Inflammation in the brain is a prominent feature in Alzheimer's disease (AD). Recent studies suggest that chronic inflammation can be a consequence of failure to resolve the inflammation. Resolution of inflammation is mediated by a family of lipid mediators (LMs), and the levels of these specialized pro-resolving mediators (SPMs) are reduced in the hippocampus of those with AD. In the present study, we combined analysis of LMs in the entorhinal cortex (ENT) from AD patients with in vitro analysi ...[more]