Unknown

Dataset Information

0

Estrogen induces multiple regulatory B cell subtypes and promotes M2 microglia and neuroprotection during experimental autoimmune encephalomyelitis.


ABSTRACT: Sex hormones promote immunoregulatory effects on multiple sclerosis. The current study evaluated estrogen effects on regulatory B cells and resident CNS microglia during experimental autoimmune encephalomyelitis (EAE). Herein, we demonstrate an estrogen-dependent induction of multiple regulatory B cell markers indicative of IL-10 dependent as well as IFN-? dependent pathways. Moreover, although estrogen pretreatment of EAE mice inhibited the infiltration of pro-inflammatory cells into the CNS, it enhanced the frequency of regulatory B cells and M2 microglia. Our study suggests that estrogen has a broad effect on the development of regulatory B cells during EAE, which in turn could promote neuroprotection.

SUBMITTER: Benedek G 

PROVIDER: S-EPMC4824954 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature

altmetric image

Publications

Estrogen induces multiple regulatory B cell subtypes and promotes M2 microglia and neuroprotection during experimental autoimmune encephalomyelitis.

Benedek Gil G   Zhang Jun J   Zhang Jun J   Bodhankar Sheetal S   Nguyen Ha H   Kent Gail G   Jordan Kelley K   Manning Dustin D   Vandenbark Arthur A AA   Offner Halina H  

Journal of neuroimmunology 20160213


Sex hormones promote immunoregulatory effects on multiple sclerosis. The current study evaluated estrogen effects on regulatory B cells and resident CNS microglia during experimental autoimmune encephalomyelitis (EAE). Herein, we demonstrate an estrogen-dependent induction of multiple regulatory B cell markers indicative of IL-10 dependent as well as IFN-γ dependent pathways. Moreover, although estrogen pretreatment of EAE mice inhibited the infiltration of pro-inflammatory cells into the CNS, i  ...[more]

Similar Datasets

| S-EPMC1458883 | biostudies-other
| S-EPMC4481122 | biostudies-literature
| S-EPMC8126707 | biostudies-literature
| S-EPMC5998626 | biostudies-literature
| S-EPMC7555782 | biostudies-literature
| S-EPMC3260126 | biostudies-literature
| S-EPMC8542903 | biostudies-literature
| S-EPMC5725374 | biostudies-literature
| S-EPMC8720009 | biostudies-literature
2023-05-11 | GSE231833 | GEO