Ontology highlight
ABSTRACT:
SUBMITTER: Sanders JM
PROVIDER: S-EPMC4825186 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Sanders J Michael JM Coulter Sherry J SJ Knudsen Gabriel A GA Dunnick June K JK Kissling Grace E GE Birnbaum Linda S LS
Toxicology and applied pharmacology 20160315
Chronic oral treatment of tetrabromobisphenol A (TBBPA) to female Wistar Han rats resulted in increased incidence of cell proliferation at 250mg/kg and tumor formation in the uterus at higher doses. The present study was designed to test the hypothesis that disruption of estrogen homeostasis was a major mode-of-action for the observed effects. Biological changes were assessed in serum, liver, and the proximal (nearest the cervix) and distal (nearest the ovaries) sections of the uterine horn of W ...[more]