Ontology highlight
ABSTRACT:
SUBMITTER: Esen E
PROVIDER: S-EPMC4825329 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20150714 11
Teriparatide, a recombinant peptide corresponding to amino acids 1-34 of human parathyroid hormone (PTH), has been an effective bone anabolic drug for over a decade. However, the mechanism whereby PTH stimulates bone formation remains incompletely understood. Here we report that in cultures of osteoblast-lineage cells, PTH stimulates glucose consumption and lactate production in the presence of oxygen, a hallmark of aerobic glycolysis, also known as Warburg effect. Experiments with radioactively ...[more]