Ontology highlight
ABSTRACT:
SUBMITTER: Tian C
PROVIDER: S-EPMC7229204 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Tian Chunjie C Kim Yeon Ju YJ Hali Sai S Choo Oak-Sung OS Lee Jin-Sol JS Jung Seo-Kyung SK Choi Youn-Uk YU Park Chan Bae CB Choung Yun-Hoon YH
Cell death & disease 20200515 5
Age-dependent decrease of mitochondrial energy production and cellular redox imbalance play significant roles in age-related hearing loss (ARHL). Lactate dehydrogenase B (LDHB) is a key glycolytic enzyme that catalyzes the interconversion of pyruvate and lactate. LDH activity and isoenzyme patterns are known to be changed with aging, but the role of LDHB in ARHL has not been studied yet. Here, we found that LDHB knockout mice showed hearing loss at high frequencies, which is the typical feature ...[more]