Ontology highlight
ABSTRACT:
SUBMITTER: Angulo-Ibanez M
PROVIDER: S-EPMC4825733 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Angulo-Ibáñez Maria M Rovira-Clavé Xavier X Granados-Jaén Alba A Downs Bradley B Kim Yeong C YC Wang San Ming SM Reina Manuel M Espel Enric E
Cell cycle (Georgetown, Tex.) 20150101 24
An adequate supply of nucleotides is essential for accurate DNA replication, and inappropriate deoxyribonucleotide triphosphate (dNTP) concentrations can lead to replication stress, a common source of DNA damage, genomic instability and tumourigenesis. Here, we provide evidence that Erk5 is necessary for correct nucleotide supply during erythroid development. Mice with Erk5 knockout in the haematopoietic lineage showed impaired erythroid development in bone marrow, accompanied by altered dNTP le ...[more]