Ontology highlight
ABSTRACT:
SUBMITTER: Heimbucher T
PROVIDER: S-EPMC4826154 | biostudies-literature | 2015 Oct-Dec
REPOSITORIES: biostudies-literature
Heimbucher Thomas T Hunter Tony T
Worm 20151001 4
FOXO family transcription factors are downstream effectors of Insulin/IGF-1 signaling (IIS) and are regulated by posttranslational modification and coregulators, including components of the ubiquitin-proteasome system (UPS). Cofactors promoting DAF-16/FOXO protein stability and function in IIS have not been described yet. In a recent study, we have identified the deubiquitylating enzyme MATH-33, the ortholog of mammalian USP7/HAUSP, as an essential DAF-16 coregulator. We found that MATH-33 activ ...[more]