Ontology highlight
ABSTRACT:
SUBMITTER: Johansson P
PROVIDER: S-EPMC4826231 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Johansson Peter P Aoude Lauren G LG Wadt Karin K Glasson William J WJ Warrier Sunil K SK Hewitt Alex W AW Kiilgaard Jens Folke JF Heegaard Steffen S Isaacs Tim T Franchina Maria M Ingvar Christian C Vermeulen Tersia T Whitehead Kevin J KJ Schmidt Christopher W CW Palmer Jane M JM Symmons Judith J Gerdes Anne-Marie AM Jönsson Göran G Hayward Nicholas K NK
Oncotarget 20160101 4
Next generation sequencing of uveal melanoma (UM) samples has identified a number of recurrent oncogenic or loss-of-function mutations in key driver genes including: GNAQ, GNA11, EIF1AX, SF3B1 and BAP1. To search for additional driver mutations in this tumor type we carried out whole-genome or whole-exome sequencing of 28 tumors or primary cell lines. These samples have a low mutation burden, with a mean of 10.6 protein changing mutations per sample (range 0 to 53). As expected for these sun-shi ...[more]