Ontology highlight
ABSTRACT:
SUBMITTER: Wong SQ
PROVIDER: S-EPMC4359221 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Wong Stephen Q SQ Behren Andreas A Mar Victoria J VJ Woods Katherine K Li Jason J Martin Claire C Sheppard Karen E KE Wolfe Rory R Kelly John J Cebon Jonathan J Dobrovic Alexander A McArthur Grant A GA
Oncotarget 20150101 2
Melanoma is often caused by mutations due to exposure to ultraviolet radiation. This study reports a recurrent somatic C > T change causing a P131L mutation in the RQCD1 (Required for Cell Differentiation1 Homolog) gene identified through whole exome sequencing of 20 metastatic melanomas. Screening in 715 additional primary melanomas revealed a prevalence of ~4%. This represents the first reported recurrent mutation in a member of the CCR4-NOT complex in cancer. Compared to tumors without the mu ...[more]